Article
Ovarian cancer familial relative risks by tumour subtypes and by known ovarian cancer genetic susceptibility variants.
Journal of medical genetics - 1 Feb 2014
Jervis Sarah, Song Honglin, Lee Andrew, Dicks Ed, Tyrer Jonathan, Harrington Patricia, Easton Douglas F, Jacobs Ian J, Pharoah Paul P D, Antoniou Antonis C
Abstract excerpt
BACKGROUND: Family history is one of the most important risk factors for epithelial ovarian cancer (EOC). Little is known, however, on how EOC familial relative risks (FRRs) vary by factors such as tumour subtype or the combined effects of common EOC susceptibility alleles. In addition, no data currently exist on the FRRs associated with EOC after exclusion of BRCA1 or BRCA2 mutation carriers. METHODS: EOC FRRs...
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