Quinine Bitterness and Grapefruit Liking Associate with Allelic Variants in TAS2R31.

doi:10.1093/chemse/bjv027

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Quinine Bitterness and Grapefruit Liking Associate with Allelic Variants in TAS2R31.

Chemical senses - 1 Jul 2015

Hayes John E, Feeney Emma L, Nolden Alissa A, McGeary John E

Abstract excerpt

Multiple psychophysical gene-association studies suggest a single nucleotide polymorphism (SNP) within the bitter receptor gene TAS2R19 on chromosome 12 may be functional. Previously, the Arg299Cys SNP (rs10772420) has been associated with differential bitterness of quinine and differential liking for grapefruit juice. However, quinine does not activate TAS2R19 in vitro; likewise, limonin and naringin, bitter...

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PMID: 26024668
DOI: 10.1093/chemse/bjv027
PMCID: PMC4542653

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