Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: Differences between primary and cancer cells

29 Apr 2013

Abstract excerpt

The molecular mechanism of Salinomycin's toxicity is not fully understood. Various studies reported that Ca(2+), cytochrome c, and caspase activation play a role in Salinomycin-induced cytotoxicity. Furthermore, Salinomycin may target Wnt/β-catenin signaling pathway to promote differentiation and thus elimination of cancer stem cells. In this study, we show a massive autophagic response to Salinomycin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Epigenetics and DNA Methylation
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23639289
DOI: 10.1016/j.bbamcr.2013.04.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: Differences between primary and cancer cellsPMID 23639289Read ↗

Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cellsSemantic proximity Read ↗

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious diseaseSemantic proximity Read ↗

Salinomycin as a Drug for Targeting Human Cancer Stem CellsSemantic proximity Read ↗

Platycodin D, a bioactive component of Platycodon grandiflorum, induces cancer cell death associated with extreme vacuolationSemantic proximity Read ↗

Targeting cancer cells through antibiotics-induced mitochondrial dysfunction requires autophagy inhibitionSemantic proximity Read ↗

An iron hand over cancer stem cellsSemantic proximity Read ↗

C28-induced autophagy of female germline stem cells in vitro and its potential mechanismsSemantic proximity Read ↗

Antitumor properties of salinomycin on cisplatin-resistant human ovarian cancer cells in vitro and in vivo: Involvement of p38 MAPK activationSemantic proximity Read ↗

Induction of G1 Cell Cycle Arrest in Human Glioma Cells by Salinomycin Through Triggering ROS-Mediated DNA Damage In Vitro and In VivoSemantic proximity Read ↗

ROS-p53-cyclophilin-D signaling mediates salinomycin-induced glioma cell necrosisSemantic proximity Read ↗

Loss of Mitochondrial DNA by Gemcitabine Triggers Mitophagy and Cell DeathSemantic proximity Read ↗

The role of reactive oxygen species and autophagy in safingol-induced cell deathSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.