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Article

Phenotyping drug polypharmacology via eicosanoid profiling of blood.

Journal of lipid research - 1 Aug 2015

Song Jiao, Liu Xuejun, Rao Tadimeti S, Chang Leon, Meehan Michael J, Blevitt Jonathan M, Wu Jiejun, Dorrestein Pieter C, Milla Marcos E

Abstract excerpt

It is widely accepted that small-molecule drugs, despite their selectivity at primary targets, exert pharmacological effects (and safety liabilities) through a multiplicity of pathways. As such, it has proved extremely difficult to experimentally assess polypharmacology in an agnostic fashion. Profiling of metabolites produced as part of physiological responses to pharmacological stimuli provides a unique...

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PMID: 26022804
DOI: 10.1194/jlr.M058677
PMCID: PMC4513990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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