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Article

Phenotyping drug polypharmacology via eicosanoid profiling of blood.

Journal of lipid research - 1 Aug 2015

Song Jiao, Liu Xuejun, Rao Tadimeti S, Chang Leon, Meehan Michael J, Blevitt Jonathan M, Wu Jiejun, Dorrestein Pieter C, Milla Marcos E

Abstract excerpt

It is widely accepted that small-molecule drugs, despite their selectivity at primary targets, exert pharmacological effects (and safety liabilities) through a multiplicity of pathways. As such, it has proved extremely difficult to experimentally assess polypharmacology in an agnostic fashion. Pr...

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Identifiers

PMID: 26022804
DOI: 10.1194/jlr.M058677
PMCID: PMC4513990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26022804-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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