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Article

Application of Combination High-Throughput Phenotypic Screening and Target Identification Methods for the Discovery of Natural Product-Based Combination Drugs.

Medicinal research reviews - 1 Mar 2018

Isgut Monica, Rao Mukkavilli, Yang Chunhua, Subrahmanyam Vangala, Rida Padmashree C G, Aneja Ritu

Abstract excerpt

Modern drug discovery efforts have had mediocre success rates with increasing developmental costs, and this has encouraged pharmaceutical scientists to seek innovative approaches. Recently with the rise of the fields of systems biology and metabolomics, network pharmacology (NP) has begun to emerge as a new paradigm in drug discovery, with a focus on multiple targets and drug combinations for treating disease....

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PMID: 28510271
DOI: 10.1002/med.21444

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