Article

Identifying pyrogenic contaminants using transcriptomic profiling of monocyte activation test with machine learning

2025-08-18

Abstract excerpt

<h4>ABSTRACT</h4> The monocyte activation test is an in vitro pyrogenicity assessment method that can utilise human peripheral blood mononuclear cells to detect pyrogens in injectable drugs, providing a binary outcome that indicates the presence or absence of a pyrogen. The added ability to distinguish between different types of pyrogens would greatly expand the applicability of the test, for example, by allowin...

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Literature Corpus work: 2e8770ba-dbb0-5edc-8292-d5a4f184a4d7
DOI: 10.1101/2025.08.13.670109

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