Article
Identification of novel chimpanzee MHC class I and II alleles using an improved sequence-based typing strategy.
Human immunology - 1 Jan 2000
Caggiari Laura, Simula Maria Paola, Marzotto Alessandra, Shiina Masaaki, Rehermann Barbara, De Re Valli
Abstract excerpt
The chimpanzee (Pan troglodytes) is a valuable model for the study of infection with hepatitis C virus and hepatitis B virus, to which only humans and chimpanzees are susceptible. Because the cellular immune response plays a crucial role in host defense against these viruses, the analysis of major histocompatibility complex (MHC) (Patr) class I and II allele diversity in chimpanzees is essential for immune...
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