Article
Mutation screening of GRIN2B in schizophrenia and autism spectrum disorder in a Japanese population.
Scientific reports - 12 Sept 2016
Takasaki Yuto, Koide Takayoshi, Wang Chenyao, Kimura Hiroki, Xing Jingrui, Kushima Itaru, Ishizuka Kanako, Mori Daisuke, Sekiguchi Mariko, Ikeda Masashi, Aizawa Miki, Tsurumaru Naoko, Iwayama Yoshimi, Yoshimi Akira, Arioka Yuko, Yoshida Mami, Noma Hiromi, Oya-Ito Tomoko, Nakamura Yukako, Kunimoto Shohko, Aleksic Branko, Uno Yota, Okada Takashi, Ujike Hiroshi, Egawa Jun, Kuwabara Hitoshi, Someya Toshiyuki, Yoshikawa Takeo, Iwata Nakao, Ozaki Norio
Abstract excerpt
N-methyl-d-aspartate receptors (NMDARs) play a critical role in excitatory synaptic transmission and plasticity in the central nervous systems. Recent genetics studies in schizophrenia (SCZ) show that SCZ is susceptible to NMDARs and the NMDAR signaling complex. In autism spectrum disorder (ASD), several studies report dysregulation of NMDARs as a risk factor for ASD. To further examine the association between...
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