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Article

Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 May 2015

Yang Weili, Wang Guohao, Wang Chuan-En, Guo Xiangyu, Yin Peng, Gao Jinquan, Tu Zhuchi, Wang Zhengbo, Wu Jing, Hu Xintian, Li Shihua, Li Xiao-Jiang

Abstract excerpt

Parkinson's disease (PD) is an age-dependent neurodegenerative disease that often occurs in those over age 60. Although rodents and small animals have been used widely to model PD and investigate its pathology, their short life span makes it difficult to assess the aging-related pathology that is likely to occur in PD patient brains. Here, we used brain tissues from rhesus monkeys at 2-3, 7-8, and >15 years of...

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Identifiers

PMID: 26019347
DOI: 10.1523/JNEUROSCI.0772-15.2015
PMCID: PMC4444551

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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