Article
Programmed Death-Ligand 1 Expression Predicts Tyrosine Kinase Inhibitor Response and Better Prognosis in a Cohort of Patients With Epidermal Growth Factor Receptor Mutation-Positive Lung Adenocarcinoma.
Clinical lung cancer - 1 Sept 2015
Lin Cheng, Chen Xiong, Li Meifang, Liu Jingnan, Qi Xingfeng, Yang Wenting, Zhang Hairong, Cai Zhongfu, Dai Yun, Ouyang Xuenong
Abstract excerpt
BACKGROUND: The immune checkpoint proteins programmed death-1/ligand (PD-1/PD-L1) play a critical role in immune escape of tumor cells. In models of epidermal growth factor receptor (EGFR)-driven non-small-cell lung cancer (NSCLC), EGFR signal upregulates PD-1/PD-L1. However, data on the clinical significance of PD1/PD-L1 expression in patients with the subtype of NSCLC carrying EGFR mutations remain limited....
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