Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emerging Role of ODC1 in Neurodevelopmental Disorders and Brain Development.

Genes - 25 Mar 2021

Prokop Jeremy W, Bupp Caleb P, Frisch Austin, Bilinovich Stephanie M, Campbell Daniel B, Vogt Daniel, Schultz Chad R, Uhl Katie L, VanSickle Elizabeth, Rajasekaran Surender, Bachmann André S

Abstract excerpt

Ornithine decarboxylase 1 (ODC1 gene) has been linked through gain-of-function variants to a rare disease featuring developmental delay, alopecia, macrocephaly, and structural brain anomalies. ODC1 has been linked to additional diseases like cancer, with growing evidence for neurological contributions to schizophrenia, mood disorders, anxiety, epilepsy, learning, and suicidal behavior. The evidence of ODC1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondrial Membrane Transport Proteins

Share to Neural Stem Cells

Share to Neurodevelopmental Disorders

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 33806076
DOI: 10.3390/genes12040470
PMCID: PMC8064465

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emerging Role of ODC1 in Neurodevelopmental Disorders and Brain Development.PMID 33806076Read ↗

Expanding the phenotype: Four new cases and hope for treatment in Bachmann-Bupp syndrome.Semantic proximity Read ↗

De novo mutation of cancer-related genes associates with particular neurodevelopmental disorders.Semantic proximity Read ↗

Genomic and Transcriptomic Signatures of SETD1A Disruption in Human Excitatory Neuron Development and Psychiatric Disease RiskSemantic proximity Read ↗

De novo variants predicting haploinsufficiency for DIP2C are associated with expressive speech delay.Semantic proximity Read ↗

Individuals with intellectual disability have an increased burden of <i>de novo</i> variants in <i>cis</i>-regulatory elements of glutamatergic neuronsSemantic proximity Read ↗

Response to Comment on "Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment".Semantic proximity Read ↗

A novel splice variant in EMC1 is associated with cerebellar atrophy, visual impairment, psychomotor retardation with epilepsy.Semantic proximity Read ↗

Integrative multi-omic analysis reveals neurodevelopmental gene dysregulation in CIC-knockout and IDH1-mutant cells.Semantic proximity Read ↗

Identification of<i>de novo</i>mutations in prenatal neurodevelopment-associated genes in schizophrenia in two Han Chinese patient-sibling family-based cohortsSemantic proximity Read ↗

SETD1B-associated neurodevelopmental disorder.Semantic proximity Read ↗

CIC-Related Neurodevelopmental Disorder: A Review of the Literature and an Expansion of Genotype and Phenotype.Semantic proximity Read ↗

Novel truncating and missense variants extending the spectrum of EMC1-related phenotypes, causing autism spectrum disorder, severe global development delay and visual impairment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.