The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification

doi:10.1002/ijc.25074

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The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification

3 Dec 2009

Abstract excerpt

High polyamine (PA) levels and ornithine decarboxylase (ODC) overexpression are well-known phenomena in many aggressive cancer types. We analyzed the expression of ODC and ODC-activity regulating genes antizymes 1-3 (OAZ1-3) and antizyme inhibitors 1-2 (AZ-IN1-2) in human neuroblastoma (NB) tumors and correlated these with genetic and clinical features of NB. Since ODC is a known target gene of MYCN, the...

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PMID: 19960435
DOI: 10.1002/ijc.25074

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The polyamine metabolism genes <i>ornithine decarboxylase</i> and <i>antizyme 2</i> predict aggressive behavior in neuroblastomas with and without <i>MYCN</i> amplification

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