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Article

Alterations of Wnt/β-catenin signaling pathway in hepatocellular carcinomas associated with hepatitis C virus.

Polish journal of pathology : official journal of the Polish Society of Pathologists - 1 Mar 2015

Rogacki Karol, Kasprzak Aldona, Stępiński Adrian

Abstract excerpt

The Wnt/Fzd/β-catenin signaling pathway plays a significant role in physiology and pathology of the liver. The role of β-catenin is linked mainly to the canonical pathway of the system. Phosphorylation of β-catenin and abnormalities in function of the E-cadherin-catenin unit lead to loss of intercellular junctions, progression in liver fibrosis, and development of cirrhosis and hepatocellular carcinoma (HCC)....

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Source

Identifiers

PMID: 26017875
DOI: 10.5114/pjp.2015.51148

Genes

CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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