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Article

BHMT G742A and MTHFD1 G1958A polymorphisms and Down syndrome risk in the Brazilian population.

Genetic testing and molecular biomarkers - 1 Jun 2012

Zampieri Bruna Lancia, Biselli Joice Matos, Goloni-Bertollo Eny Maria, Pavarino Erika Cristina

Abstract excerpt

BACKGROUND: Mechanisms underlying meiotic nondisjunction are poorly understood. Attempts to elucidate the causes of Down syndrome (DS) have analyzed the relationship between polymorphism in folate metabolism and DS. AIM: The role of methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) G1958A and betaine-homocysteine methyltransferase (BHMT) G742A polymorphisms in DS risk was investigated. METHODS: Blood samples...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22339736
DOI: 10.1089/gtmb.2011.0257

Genes

BHMT
MTHFD1

Variants

Provenance

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