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Article

Association between MTHFR C677T and A1298C gene polymorphisms and maternal risk for Down syndrome: A protocol for systematic review and/or meta-analysis.

Medicine - 21 Jan 2022

Ginani Carla Talita Azevedo, Luz Jefferson Romáryo Duarte da, Silva Saulo Victor E, Coppedè Fabio, Almeida Maria das Graças

Abstract excerpt

BACKGROUND: Down syndrome (DS) is one of the most common chromosomal abnormalities among live-born babies and one of the best-known intellectual disability disorders in humans. Errors leading to trisomy 21 are primarily arising from defects in chromosomal segregation during maternal meiosis (about 88% of cases), and the focus of many investigations has been to identify maternal risk factors favoring chromosome 21...

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Source

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Identifiers

PMID: 35060496
DOI: 10.1097/MD.0000000000028293
PMCID: PMC8772651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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