Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms of the MTHFR gene in mothers of children with trisomy 21 (Down syndrome) in a Polish population.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University - 1 Feb 2020

Czechowicz Paulina, Małodobra-Mazur Małgorzata, Lebioda Arleta, Jonkisz Anna, Dobosz Tadeusz, Śmigiel Robert

Abstract excerpt

BACKGROUND: Down syndrome (DS) is the most frequent cause of intellectual disability. In 95% of cases, it is caused by simple trisomy of chromosome 21 resulting from nondisjunction of chromosomes in meiotic division. Currently, the molecular and cellular mechanisms responsible for the phenomenon of nondisjunction are unknown. OBJECTIVES: To investigate the incidence of 5 single-nucleotide polymorphisms (SNPs) of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down Syndrome

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Mothers

Share to Poland

Share to Pregnancy

Share to Risk Factors

Source

Identifiers

PMID: 32073761
DOI: 10.17219/acem/115078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms of the MTHFR gene in mothers of children with trisomy 21 (Down syndrome) in a Polish population.PMID 32073761Read ↗

Polymorphisms of the MTHFR Gene in Mothers of Children with Trisomy 21 (Down Syndrome) in a Polish PopulationSemantic proximity Read ↗

Association between MTHFR C677T and A1298C gene polymorphisms and maternal risk for Down syndrome: A protocol for systematic review and/or meta-analysis.Semantic proximity Read ↗

MTHFR C677T and A1298C polymorphisms are risk factors for Down's syndrome in Indian mothers.Semantic proximity Read ↗

MTHFR gene polymorphism and associated nutritional deficiency in the etiology and pathogenesis of Down syndromeSemantic proximity Read ↗

<i>MTHFR</i>Gene variants C677T, A1298C and association with Down syndrome: A case-control study from South IndiaSemantic proximity Read ↗

Association of C677T and A1298C polymorphisms of the MTHFR gene with maternal risk for Down syndrome: A meta-analysis of case-control studies.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase enzyme polymorphisms as maternal risk for Down syndrome among Turkish women.Semantic proximity Read ↗

The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defectsSemantic proximity Read ↗

Maternal methylenetetrahydrofolate reductase C677T polymorphism and down syndrome risk: a meta-analysis from 34 studies.Semantic proximity Read ↗

BHMT G742A and MTHFD1 G1958A polymorphisms and Down syndrome risk in the Brazilian population.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphisms C677T and A1298C as maternal risk factors for Down syndrome in Jordan.Semantic proximity Read ↗

Maternal MTHFR polymorphism (677 C-T) and risk of Down's syndrome child: meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.