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Article

Next-generation sequencing offers new insights into the resistance of Candida spp. to echinocandins and azoles.

The Journal of antimicrobial chemotherapy - 1 Sept 2015

Garnaud Cécile, Botterel Françoise, Sertour Natacha, Bougnoux Marie-Elisabeth, Dannaoui Eric, Larrat Sylvie, Hennequin Christophe, Guinea Jesus, Cornet Muriel, Maubon Danièle

Abstract excerpt

OBJECTIVES: MDR Candida strains are emerging. Next-generation sequencing (NGS), which enables extensive and deep genome analysis, was used to investigate echinocandin and azole resistance in clinical Candida isolates. METHODS: Six genes commonly involved in antifungal resistance (ERG11, ERG3, TAC1, CgPDR1, FKS1 and FKS2) were analysed using NGS in 40 Candida isolates (18 Candida albicans, 15 Candida glabrata and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26017039
DOI: 10.1093/jac/dkv139

Genes

TAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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