Article
Large-scale genome mining allows identification of neutral polymorphisms and novel resistance mutations in genes involved in Candida albicans resistance to azoles and echinocandins.
The Journal of antimicrobial chemotherapy - 1 Apr 2020
Sitterlé Emilie, Coste Alix T, Obadia Thomas, Maufrais Corinne, Chauvel Murielle, Sertour Natacha, Sanglard Dominique, Puel Anne, D'Enfert Christophe, Bougnoux Marie-Elisabeth
Abstract excerpt
BACKGROUND: The genome of Candida albicans displays significant polymorphism. Point mutations in genes involved in resistance to antifungals may either confer phenotypic resistance or be devoid of phenotypic consequences. OBJECTIVES: To catalogue polymorphisms in azole and echinocandin resistance genes occurring in susceptible strains in order to rapidly pinpoint relevant mutations in resistant strains. METHODS:...
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