Article
Genomic description of acquired fluconazole- and echinocandin-resistance in patients with serial Candida glabrata isolates.
Journal of clinical microbiology - 14 Feb 2024
Misas E, Seagle E, Jenkins E N, Rajeev M, Hurst S, Nunnally N S, Bentz M L, Lyman M M, Berkow E, Harrison L H, Schaffner W, Markus T M, Pierce R, Farley M M, Chow N A, Lockhart S R, Litvintseva A P
Abstract excerpt
Candida glabrata is one of the most common causes of systemic candidiasis, often resistant to antifungal medications. To describe the genomic context of emerging resistance, we conducted a retrospective analysis of 82 serially collected isolates from 33 patients from population-based candidemia surveillance in the United States. We used whole-genome sequencing to determine the genetic relationships between...
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