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Article

Stepwise emergence of azole, echinocandin and amphotericin B multidrug resistance in vivo in Candida albicans orchestrated by multiple genetic alterations.

The Journal of antimicrobial chemotherapy - 1 Sept 2015

Jensen Rasmus Hare, Astvad Karen Marie Thyssen, Silva Luis Vale, Sanglard Dominique, Jørgensen Rene, Nielsen Kristian Fog, Mathiasen Estella Glintborg, Doroudian Ghazalel, Perlin David Scott, Arendrup Maiken Cavling

Abstract excerpt

OBJECTIVES: The objective of this study was to characterize the underlying molecular mechanisms in consecutive clinical Candida albicans isolates from a single patient displaying stepwise-acquired multidrug resistance. METHODS: Nine clinical isolates (P-1 to P-9) were susceptibility tested by EUCAST EDef 7.2 and Etest. P-4, P-5, P-7, P-8 and P-9 were available for further studies. Relatedness was evaluated by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26017038
DOI: 10.1093/jac/dkv140
PMCID: PMC4553713

Genes

CDR2
TAC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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