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Article

Inter-Regulation of Kv4.3 and Voltage-Gated Sodium Channels Underlies Predisposition to Cardiac and Neuronal Channelopathies.

International journal of molecular sciences - 17 Jul 2020

Clatot Jérôme, Neyroud Nathalie, Cox Robert, Souil Charlotte, Huang Jing, Guicheney Pascale, Antzelevitch Charles

Abstract excerpt

BACKGROUND: Genetic variants in voltage-gated sodium channels (Nav) encoded by SCNXA genes, responsible for INa, and Kv4.3 channels encoded by KCND3, responsible for the transient outward current (Ito), contribute to the manifestation of both Brugada syndrome (BrS) and spinocerebellar ataxia (SCA19/22). We examined the hypothesis that Kv4.3 and Nav variants regulate each other's function, thus modulating INa/Ito...

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Identifiers

PMID: 32709127
DOI: 10.3390/ijms21145057
PMCID: PMC7404392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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