Article
PhosSNPs-Regulated Gene Network and Pathway Significant for Rheumatoid Arthritis.
Human heredity - 1 Jan 2021
He Pei, Jiang Fei, Guo Wei, Guo Yu-Fan, Lei Shu-Feng, Deng Fei-Yan
Abstract excerpt
OBJECTIVES: Peripheral blood mononuclear cells (PBMCs) are critical for immunity and participate in multiple human diseases, including rheumatoid arthritis (RA). PhosSNPs are nonsynonymous SNPs influencing protein phosphorylation, thus probably modulate cell signaling and gene expression. We aimed to identify phosSNPs-regulated gene network/pathway potentially significant for RA. METHODS: We collected genome-wide...
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