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Article

Use of whole exome sequencing for the identification of Ito-based arrhythmia mechanism and therapy.

Journal of the American Heart Association - 26 May 2015

Sturm Amy C, Kline Crystal F, Glynn Patric, Johnson Benjamin L, Curran Jerry, Kilic Ahmet, Higgins Robert S D, Binkley Philip F, Janssen Paul M L, Weiss Raul, Raman Subha V, Fowler Steven J, Priori Silvia G, Hund Thomas J, Carnes Cynthia A, Mohler Peter J

Abstract excerpt

BACKGROUND: Identified genetic variants are insufficient to explain all cases of inherited arrhythmia. We tested whether the integration of whole exome sequencing with well-established clinical, translational, and basic science platforms could provide rapid and novel insight into human arrhythmia pathophysiology and disease treatment. METHODS AND RESULTS: We report a proband with recurrent ventricular...

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Source

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Identifiers

PMID: 26015324
DOI: 10.1161/JAHA.114.001762
PMCID: PMC4599408

Genes

DPP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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