Article
Arrhythmic Risk Stratification of Carriers of Filamin C Truncating Variants.
JAMA cardiology - 1 Apr 2025
Gigli Marta, Stolfo Davide, Barbati Giulia, Graw Sharon, Chen Suet Nee, Merlo Marco, Medo Kristen, Gregorio Caterina, Dal Ferro Matteo, Paldino Alessia, Perotto Maria, Peter van Tintelen J, Te Riele Anneline S J M, Baas Annette F, Wilde Arthur M, Amin Ahmad S, Houweling Arjan C, Elliott Perry, Cannie Douglas, Michels Michelle, Schoonvelde Stephan A C, Prasad Sanjay, Tayal Paz Upasana, Yazdani Momina, Morris-Rosendahl Deborah, Garcia-Pavia Pablo, Cabrera-Romero Eva, Bauce Barbara, Pilichou Kalliopi, Fatkin Diane, Johnson Renee, Judge Daniel P, Foil Kimberly L, Heymans Stephane, Verdonschot Job A J, Stroeks Sophie L V M, Lakdawala Neal K, Anisha Purohit, O'Neill Matthew, Shoemaker M Benjamin, Roden Dan M, Calkins Hugh, James Cynthia A, Murray Brittney, Parikh Victoria N, Ashley Euan A, Reuter Chloe, Imazio Massimo, Canepa Marco, Ameri Pietro, Song Jiangping, Sinagra Gianfranco, Taylor Matthew R G, Mestroni Luisa
Abstract excerpt
Importance: Filamin C truncating variants (FLNCtv) are a rare cause of cardiomyopathy with heterogeneous phenotypic presentations. Despite a high incidence of life-threatening ventricular arrhythmias and sudden cardiac death (SCD), reliable risk predictors to stratify carriers of FLNCtv are lacking. Objective: To determine factors predictive of SCD/major ventricular arrhythmias (MVA) in carriers of FLNCtv....
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