Article
Whole-exome sequencing reveals a rare missense variant in DTNA in an Iranian pedigree with early-onset atrial fibrillation.
BMC cardiovascular disorders - 11 Feb 2022
Malakootian Mahshid, Jalilian Masoumeh, Kalayinia Samira, Hosseini Moghadam Maryam, Heidarali Mona, Haghjoo Majid
Abstract excerpt
Atrial fibrillation (AF) is a morbid and heritable irregular cardiac rhythm that affects about 2%-3% of the population. Patients with early-onset AF have a strong genetic association with the disease; nonetheless, the exact underlying mechanisms need clarification. We herein present our evaluation of a 2-generation Iranian pedigree with early-onset AF. Whole-exome sequencing was applied to elucidate the genetic...
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