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Article

Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication.

EMBO reports - 1 Jun 2017

Hanke Leo, Schmidt Florian I, Knockenhauer Kevin E, Morin Benjamin, Whelan Sean Pj, Schwartz Thomas U, Ploegh Hidde L

Abstract excerpt

The transcription and replication machinery of negative-stranded RNA viruses presents a possible target for interference in the viral life cycle. We demonstrate the validity of this concept through the use of cytosolically expressed single-domain antibody fragments (VHHs) that protect cells from a lytic infection with vesicular stomatitis virus (VSV) by targeting the viral nucleoprotein N. We define the binding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28396572
DOI: 10.15252/embr.201643764
PMCID: PMC5452021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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