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Impact of ALDH1A1 and NQO1 gene polymorphisms on the response and toxicity of chemotherapy in Bangladeshi breast cancer patients.

Cancer chemotherapy and pharmacology - 1 Oct 2024

Islam Md Siddiqul, Akter Ferdowsi, Rahman Md Mosiqur, Rafe Md Rajdoula, Aziz Md Abdul, Parvin Salma, Mosaddek Abu Syed Md, Islam Mohammad Safiqul, Akter Md Wahid

Abstract excerpt

PURPOSE: Cyclophosphamide, Epirubicin/Doxorubicin, 5-fluorouracil (CEF or CAF) chemotherapy has long been a standard first-line treatment for breast cancer. The genetic variations of enzymes that are responsible for the metabolism of these drugs have been linked to altered treatment response and toxicity. Two drug-metabolizing enzymes ALDH1A1 and NQO1 are critically involved in the pathways of CEF/CAF metabolism....

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Source

Identifiers

PMID: 39012380
DOI: 10.1007/s00280-024-04700-5

Genes

ALDH1A1
NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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