A Trigger Residue for Transmembrane Signaling in the Escherichia coli Serine Chemoreceptor.

doi:10.1128/JB.00274-15

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Article

A Trigger Residue for Transmembrane Signaling in the Escherichia coli Serine Chemoreceptor.

Journal of bacteriology - 1 Aug 2015

Kitanovic Smiljka, Ames Peter, Parkinson John S

Abstract excerpt

UNLABELLED: The transmembrane Tsr protein of Escherichia coli mediates chemotactic responses to environmental serine gradients. Serine binds to the periplasmic domain of the homodimeric Tsr molecule, promoting a small inward displacement of one transmembrane helix (TM2). TM2 piston displacements, in turn, modulate the structural stability of the Tsr-HAMP domain on the cytoplasmic side of the membrane to control...

Topics

Amino Acid Sequence
Bacterial Proteins
Cell Membrane
Chemotaxis
Escherichia coli
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Histidine Kinase
Membrane Proteins
Methyl-Accepting Chemotaxis Proteins
Mutation
Protein Conformation
Serine
Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 26013490
DOI: 10.1128/JB.00274-15
PMCID: PMC4518824

Genes

HAMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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