Article
The S-helix determines the signal in a Tsr receptor/adenylyl cyclase reporter.
The Journal of biological chemistry - 4 May 2012
Winkler Karin, Schultz Anita, Schultz Joachim E
Abstract excerpt
A signaling or S-helix has been identified as a conserved, up to 50-residue-long segment in diverse sensory proteins. It is present in all major bacterial lineages and in euryarchea and eukaryotes. A bioinformatic analysis shows that it connects upstream receiver and downstream output domains, e.g. in histidine kinases and bacterial adenylyl cyclases. The S-helix is modeled as a two-helical parallel coiled coil....
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