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Article

Bacterial Chemoreceptors Transmit Stimulus Signals Through Coupled Entropic Switches.

Journal of molecular biology - 1 Mar 2026

Flack Caralyn E, Parkinson John S

Abstract excerpt

Tracking ligand-induced conformational changes through transmembrane sensory proteins remains a challenge in signal transduction research. Our study followed propagation of stimulus signals through a bacterial transmembrane chemoreceptor (Tsr) that controls a cytoplasmic signaling kinase (CheA). We marked relay elements in the ∼200-Å long cytoplasmic four-helix bundle signaling domain with amino acid replacements...

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Identifiers

PMID: 41448350
DOI: 10.1016/j.jmb.2025.169614
PMCID: PMC13046427

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