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Article

Functional suppression of HAMP domain signaling defects in the E. coli serine chemoreceptor.

Journal of molecular biology - 23 Oct 2014

Lai Run-Zhi, Parkinson John S

Abstract excerpt

HAMP domains play key signaling roles in many bacterial receptor proteins. The four-helix HAMP bundle of the homodimeric Escherichia coli serine chemoreceptor (Tsr) interacts with an adjoining four-helix sensory adaptation bundle to regulate the histidine autokinase CheA bound to the cytoplasmic tip of the Tsr molecule. The adaptation helices undergo reversible covalent modifications that tune the...

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Identifiers

PMID: 25134756
DOI: 10.1016/j.jmb.2014.08.003
PMCID: PMC4188812

Genes

HAMP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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