Article
Effect of genetic ancestry on leukocyte global DNA methylation in cancer patients.
BMC cancer - 27 May 2015
Cappetta Mónica, Berdasco María, Hochmann Jimena, Bonilla Carolina, Sans Mónica, Hidalgo Pedro C, Artagaveytia Nora, Kittles Rick, Martínez Miguel, Esteller Manel, Bertoni Bernardo
Abstract excerpt
BACKGROUND: The study of genetic variants alone is not enough to explain a complex disease like cancer. Alterations in DNA methylation patterns have been associated with different types of tumor. In order to detect markers of susceptibility for the development of cutaneous melanoma and breast cancer in the Uruguayan population, we integrated genetic and epigenetic information of patients and controls. METHODS: We...
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