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Article

Global DNA hypomethylation in peripheral blood mononuclear cells as a biomarker of cancer risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2013

Friso Simonetta, Udali Silvia, Guarini Patrizia, Pellegrini Camilla, Pattini Patrizia, Moruzzi Sara, Girelli Domenico, Pizzolo Francesca, Martinelli Nicola, Corrocher Roberto, Olivieri Oliviero, Choi Sang-Woon

Abstract excerpt

BACKGROUND: Global DNA hypomethylation is an early molecular event in carcinogenesis. Whether methylation measured in peripheral blood mononuclear cells (PBMCs) DNA is a clinically reliable biomarker for early detection or cancer risk assessment is to be established. METHODS: From an original sample-set of 753 male and female adults (ages 64.8 ± 7.3 years), PBMCs DNA methylation was measured in 68 subjects with...

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Share to Chromatography, Liquid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Folic Acid

Share to Leukocytes, Mononuclear

Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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Identifiers

PMID: 23300023
DOI: 10.1158/1055-9965.EPI-12-0859
PMCID: PMC3596466

Genes

IMPACT
MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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