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Article

RAS Transformation Requires CUX1-Dependent Repair of Oxidative DNA Damage

11 Mar 2014

Abstract excerpt

The Cut homeobox 1 (CUX1) gene is a target of loss-of-heterozygosity in many cancers, yet elevated CUX1 expression is frequently observed and is associated with shorter disease-free survival. The dual role of CUX1 in cancer is illustrated by the fact that most cell lines with CUX1 LOH display amplification of the remaining allele, suggesting that decreased CUX1 expression facilitates tumor development while...

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PMID: 24618719
DOI: 10.1371/journal.pbio.1001807

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