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Article

Generation of an inbred miniature pig model of retinitis pigmentosa.

Investigative ophthalmology & visual science - 31 Jan 2012

Ross Jason W, Fernandez de Castro Juan P, Zhao Jianguo, Samuel Melissa, Walters Eric, Rios Cecilia, Bray-Ward Patricia, Jones Bryan W, Marc Robert E, Wang Wei, Zhou Liang, Noel Jennifer M, McCall Maureen A, DeMarco Paul J, Prather Randall S, Kaplan Henry J

Abstract excerpt

PURPOSE: The Pro23His (P23H) rhodopsin (RHO) mutation underlies the most common form of human autosomal dominant retinitis pigmentosa (adRP). The objective of this investigation was to establish a transgenic miniature swine model of RP using the human P23H RHO gene. METHODS: Somatic cell nuclear transfer (SCNT) was used to create transgenic miniature pigs that expressed the human P23H RHO mutation. From these...

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Source

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Identifiers

PMID: 22247487
DOI: 10.1167/iovs.11-8784
PMCID: PMC3292381

Genes

RHO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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