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Article

Preservation of photoreceptor morphology and function in P23H rats using an allele independent ribozyme.

Experimental eye research - 1 Jan 2007

Gorbatyuk M, Justilien V, Liu J, Hauswirth W W, Lewin A S

Abstract excerpt

To develop an allele independent ribozyme for the treatment of autosomal dominant retinitis pigmentosa (ADRP) associated with mutations in the rhodopsin (RHO) gene, a ribozyme targeting dog, mouse, human but not rat rhodopsin (RHO) mRNA was designed and tested in vitro. Activity of this ribozyme was tested in tissue culture by co-transfection of HEK 293 cells with plasmids expressing opsin mRNA and ribozyme,...

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Source

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Identifiers

PMID: 17083931
DOI: 10.1016/j.exer.2006.08.014
PMCID: PMC1778459

Genes

RHO
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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