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Article

A new immunodeficient retinal dystrophic rat model for transplantation studies using human-derived cells.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie - 1 Nov 2018

Thomas Biju B, Zhu Danhong, Lin Tai-Chi, Kim Young Chang, Seiler Magdalene J, Martinez-Camarillo Juan Carlos, Lin Bin, Shad Yousuf, Hinton David R, Humayun Mark S

Abstract excerpt

PURPOSE: To create new immunodeficient Royal College of Surgeons (RCS) rats by introducing the defective MerTK gene into athymic nude rats. METHODS: Female homozygous RCS (RCS-p+/RCS-p+) and male nude rats (Hsd:RH-Foxn1mu, mutation in the foxn1 gene; no T cells) were crossed to produce heterozygous F1 progeny. Double homozygous F2 progeny obtained by crossing the F1 heterozygotes was identified phenotypically...

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Share to c-Mer Tyrosine Kinase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Human Embryonic Stem Cells

Share to Immunologic Deficiency Syndromes

Share to Rats, Nude

Share to Retinal Dystrophies

Share to Retinal Pigment Epithelium

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Source

Identifiers

PMID: 30215097
DOI: 10.1007/s00417-018-4134-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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