Article
The Chaperone Activity of the Developmental Small Heat Shock Protein Sip1 Is Regulated by pH-Dependent Conformational Changes.
Molecular cell - 18 Jun 2015
Fleckenstein Tilly, Kastenmüller Andreas, Stein Martin Lorenz, Peters Carsten, Daake Marina, Krause Maike, Weinfurtner Daniel, Haslbeck Martin, Weinkauf Sevil, Groll Michael, Buchner Johannes
Abstract excerpt
Small heat shock proteins (sHsps) are ubiquitous molecular chaperones that prevent the aggregation of unfolding proteins during proteotoxic stress. In Caenorhabditis elegans, Sip1 is the only sHsp exclusively expressed in oocytes and embryos. Here, we demonstrate that Sip1 is essential for heat shock survival of reproducing adults and embryos. X-ray crystallography and electron microscopy revealed that Sip1...
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