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Article

Subcellular localization of the J-protein Sis1 regulates the heat shock response.

The Journal of cell biology - 4 Jan 2021

Feder Zoë A, Ali Asif, Singh Abhyudai, Krakowiak Joanna, Zheng Xu, Bindokas Vytas P, Wolfgeher Donald, Kron Stephen J, Pincus David

Abstract excerpt

Cells exposed to heat shock induce a conserved gene expression program, the heat shock response (HSR), encoding protein homeostasis (proteostasis) factors. Heat shock also triggers proteostasis factors to form subcellular quality control bodies, but the relationship between these spatial structures and the HSR is unclear. Here we show that localization of the J-protein Sis1, a cofactor for the chaperone Hsp70,...

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Identifiers

PMID: 33326013
DOI: 10.1083/jcb.202005165
PMCID: PMC7748816

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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