Article
Genetics of schizophrenia in the South African Xhosa.
Science (New York, N.Y.) - 31 Jan 2020
Gulsuner S, Stein D J, Susser E S, Sibeko G, Pretorius A, Walsh T, Majara L, Mndini M M, Mqulwana S G, Ntola O A, Casadei S, Ngqengelele L L, Korchina V, van der Merwe C, Malan M, Fader K M, Feng M, Willoughby E, Muzny D, Baldinger A, Andrews H F, Gur R C, Gibbs R A, Zingela Z, Nagdee M, Ramesar R S, King M-C, McClellan J M
Abstract excerpt
Africa, the ancestral home of all modern humans, is the most informative continent for understanding the human genome and its contribution to complex disease. To better understand the genetics of schizophrenia, we studied the illness in the Xhosa population of South Africa, recruiting 909 cases and 917 age-, gender-, and residence-matched controls. Individuals with schizophrenia were significantly more likely...
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