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Article

Genetic association analysis of microRNA137 and its target complex 1 with schizophrenia in Han Chinese.

Scientific reports - 8 Nov 2017

Lu Weihong, Zhang Yi, Fang Xinyu, Fan Weixing, Tang Wei, Cai Jun, Song Lisheng, Zhang Chen

Abstract excerpt

Recent genome-wide association studies (GWAS) have identified a strong association signal of microRNA137 host gene (MIR137) with schizophrenia. MIR137 dysfunction results in downregulation of presynaptic target gene complexin 1 (CPLX1) and impairs synaptic plasticity in the hippocampus. In this study, we aimed to investigate whether the variants of MIR137 and CPLX1 confer susceptibility to schizophrenia in Han...

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Identifiers

PMID: 29118371
DOI: 10.1038/s41598-017-15315-7
PMCID: PMC5678134

Genes

CPLX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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