Article
Biological underpinnings and genetic predisposition to schizophrenia within microrna-137 regulatory pathways across brain development.
Translational psychiatry - 11 Feb 2026
Stella Carol, De Hoyos Lucía, Mora Alberto, Díaz-Caneja Covadonga M, Andreu-Bernabeu Álvaro, Costas Javier, Gurriarán Xaquín, Fañanas Lourdes, Bobes Julio, González-Pinto Ana, Crespo-Facorro Benedicto, Vázquez-Bourgon Javier, Martorell Lourdes, Vilella Elisabet, Muntané Gerard, Sanchez-Gistau Vanessa, Moltó María Dolores, Rivero Olga, Arango Celso, González-Peñas Javier
Abstract excerpt
Previous studies have evaluated the role of the microRNA-137 (miRNA137) regulatory pathway in schizophrenia by using in silico or in vitro predicted target genes. These approaches do not capture the dynamic spatiotemporal nature of the miRNA137 regulatory pathway or tend to overestimate direct miRNA binding sites. To provide a more accurate representation of the miRNA137 pathway during human brain development, we...
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