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Article

JMJD3 aids in reprogramming of bone marrow progenitor cells to hepatic phenotype through epigenetic activation of hepatic transcription factors.

PloS one - 1 Jan 2017

Kochat Veena, Equbal Zaffar, Baligar Prakash, Kumar Vikash, Srivastava Madhulika, Mukhopadhyay Asok

Abstract excerpt

The strictly regulated unidirectional differentiation program in some somatic stem/progenitor cells has been found to be modified in the ectopic site (tissue) undergoing regeneration. In these cases, the lineage barrier is crossed by either heterotypic cell fusion or direct differentiation. Though studies have shown the role of coordinated genetic and epigenetic mechanisms in cellular development and...

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PMID: 28328977
DOI: 10.1371/journal.pone.0173977
PMCID: PMC5362104

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