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Article

Variable expression of microglial DAP12 and TREM2 genes in Nasu-Hakola disease.

Neurogenetics - 1 Oct 2015

Sasaki Atsushi, Kakita Akiyoshi, Yoshida Kunihiro, Konno Takuya, Ikeuchi Takeshi, Hayashi Shintaro, Matsuo Hidenori, Shioda Kei

Abstract excerpt

Nasu-Hakola disease (NHD) is a form of presenile dementia associated with sclerosing leukoencephalopathy and polycystic lipomembranous osteodysplasia. This extremely rare inherited disease is caused by mutations in either DAP12 or TREM2. The present study was designed to assess the relationship between DAP12/TREM2 genotype, mRNA and protein expression levels by both Western blotting and immunohistochemistry, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26001891
DOI: 10.1007/s10048-015-0451-3

Genes

TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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