Article
A functional soluble form of CTLA-4 is present in the serum of celiac patients and correlates with mucosal injury.
International immunology - 1 Sept 2009
Simone Rita, Brizzolara Renata, Chiappori Alessandra, Milintenda-Floriani Francesca, Natale Clelia, Greco Luigi, Schiavo Mara, Bagnasco Marcello, Pesce Giampaola, Saverino Daniele
Abstract excerpt
Celiac disease (CD) is a multifactorial disorder influenced by environmental, genetic and immunological factors. Increasing evidence showed CTLA-4 gene as an important susceptibility locus for autoimmune disorders. A native soluble cytotoxic T-lymphocyte-associated protein-4 (sCTLA-4), lacking of transmembrane sequence, has been described in several autoimmune diseases. We aimed to evaluate the presence of...
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