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Article

A pharmacokinetic comparison of two voriconazole formulations and the effect of CYP2C19 polymorphism on their pharmacokinetic profiles.

Drug design, development and therapy - 1 Jan 2015

Chung Hyewon, Lee Howard, Han Hye Kyung, An Hyungmi, Lim Kyoung Soo, Lee Yong Jin, Cho Joo-Youn, Yoon Seo Hyun, Jang In-Jin, Yu Kyung-Sang

Abstract excerpt

PURPOSE: SYP-1018 is a lyophilized polymeric nanoparticle formulation of voriconazole that is under development for intravenous dosing. This study compared the pharmacokinetic and tolerability profiles of SYP-1018 with those of Vfend(®), the marketed formulation of voriconazole. The effect of CYP2C19 polymorphism on the voriconazole pharmacokinetics was also evaluated. METHODS: An open-label, two-treatment,...

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Identifiers

PMID: 25999694
DOI: 10.2147/DDDT.S80066
PMCID: PMC4435089

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SYP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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