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Article

Molecular mechanism of c-Myc and PRPS1/2 against thiopurine resistance in Burkitt's lymphoma.

Journal of cellular and molecular medicine - 1 Jun 2020

Li Ting, Song Lili, Zhang Yingwen, Han Yali, Zhan Zhiyan, Xv Zhou, Li Yang, Tang Yuejia, Yang Yi, Wang Siqi, Li Shanshan, Zheng Liang, Li Yanxin, Gao Yijin

Abstract excerpt

Patients with relapsed/refractory Burkitt's lymphoma (BL) have a dismal prognosis. Current research efforts aim to increase cure rates by identifying high-risk patients in need of more intensive or novel therapy. The 8q24 chromosomal translocation of the c-Myc gene, a main molecular marker of BL, is related to the metabolism by regulating phosphoribosyl pyrophosphate synthetase 2 (PRPS2). In our study, BL showed...

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PMID: 32391636
DOI: 10.1111/jcmm.15322
PMCID: PMC7299692

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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