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Polyploidy and liver proliferation: Central role of insulin signaling

1 Feb 2010

Abstract excerpt

The formation of polyploid cells is part of the developmental program in several tissues. Polyploidy is a characteristic feature of mammalian hepatocytes and it is emerging that this process is an important mechanism of restricting liver growth. We previously demonstrated that during post-natal development, binucleated tetraploid hepatocytes arise due to a failure in cytokinesis. The genesis of such binucleated...

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PMID: 20090410
DOI: 10.4161/cc.9.3.10542

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