Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HDAC4 overexpression predicts aggressive phenotypes and poor outcomes in urothelial carcinoma.

Cancer treatment and research communications - 1 Jan 2026

Jan Hau-Chern, Su Ying-Chieh, Huang Steven Kuan-Hua, Wang Chu-An, Wang Ju-Ming, Li Chien-Feng

Abstract excerpt

BACKGROUND: Aberrant epigenetic regulation contributes to cancer progression. Transcriptome profiling of bladder urothelial carcinoma (UBUC) (GSE31684) revealed that HDAC4 upregulation is associated with metastasis. However, its prognostic value in urothelial carcinoma (UC) remains unclear. This study aimed to evaluate the clinical significance of HDAC4 expression in UC. PATIENTS AND METHODS: Tumor specimens from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Carcinoma, Transitional Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Histone Deacetylases

Share to Kaplan-Meier Estimate

Share to Prognosis

Share to Repressor Proteins

Share to Urinary Bladder Neoplasms

Source

Identifiers

PMID: 41861537
DOI: 10.1016/j.ctarc.2026.101148

Genes

HDAC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HDAC4 overexpression predicts aggressive phenotypes and poor outcomes in urothelial carcinoma.PMID 41861537Read ↗

Effects of novel HDAC inhibitors on urothelial carcinoma cellsSemantic proximity Read ↗

Revisiting Histone Deacetylases in Human Tumorigenesis: The Paradigm of Urothelial Bladder CancerSemantic proximity Read ↗

The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells.Semantic proximity Read ↗

The expression of histone deacetylase HDAC1 correlates with the progression and prognosis of gastrointestinal malignancySemantic proximity Read ↗

SIRT4 is an independent prognostic factor in bladder cancer and inhibits bladder cancer growth by suppressing autophagySemantic proximity Read ↗

SWI/SNF Alterations Define a Chromatin-Dependent Subtype of Urothelial CarcinomaSemantic proximity Read ↗

Limited efficacy of specific HDAC6 inhibition in urothelial cancer cellsSemantic proximity Read ↗

HDAC11: A novel target for improved cancer therapySemantic proximity Read ↗

Epigenetic modulation elicits an NK cell-mediated immune response in urothelial carcinomaSemantic proximity Read ↗

Role of HDAC6 and Its Selective Inhibitors in Gastrointestinal CancerSemantic proximity Read ↗

Characterization of Histone Deacetylase Expression Within In Vitro and In Vivo Bladder Cancer Model SystemsSemantic proximity Read ↗

Overexpression of maelstrom promotes bladder urothelial carcinoma cell aggressiveness by epigenetically downregulating MTSS1 through DNMT3BSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.