Article
Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification.
Genome biology - 22 May 2015
Ng Charlotte K Y, Martelotto Luciano G, Gauthier Arnaud, Wen Huei-Chi, Piscuoglio Salvatore, Lim Raymond S, Cowell Catherine F, Wilkerson Paul M, Wai Patty, Rodrigues Daniel N, Arnould Laurent, Geyer Felipe C, Bromberg Silvio E, Lacroix-Triki Magali, Penault-Llorca Frederique, Giard Sylvia, Sastre-Garau Xavier, Natrajan Rachael, Norton Larry, Cottu Paul H, Weigelt Britta, Vincent-Salomon Anne, Reis-Filho Jorge S
Abstract excerpt
BACKGROUND: HER2 is overexpressed and amplified in approximately 15% of invasive breast cancers, and is the molecular target and predictive marker of response to anti-HER2 agents. In a subset of these cases, heterogeneous distribution of HER2 gene amplification can be found, which creates clinically challenging scenarios. Currently, breast cancers with HER2 amplification/overexpression in just over 10% of cancer...
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